Abstract #3016
Assessment of aquaporins function in stages of clinical liver fibrosis using multi-b DWI
Qiuju Li 1 , Qiyong Guo 1 , Zhoushe Zhao 2 , Jiahui Li 1 , Bing Yu 1 , and Yu Shi 1
1
Radiology, shengjing hospital, Shenyang,
Liaoning, China,
2
General
Electronic Company Healthcare (China), General
Electronic Company Healthcare (China), Beijing, Beijing,
China
A multi-b DWI was to investigate the value of aquaporins
function in diagnosis of early liver fibrosis in
patients. At low-b values, the resulted ADCs reflected
the hepatic blood perfusion information while the
functional changes of the AQPs on cell membranes at high
b values. The "standard" ADC value obtained by
conventional method and low-b, mid-b and high-b ADC
value mesured by tri-exponential model all can
distinguish normal from cirrhosis of the liver tissue.
The "standard" ADC value can be hardly used to grade
early liver fibrosis. However, both low-b values and
high-b ADC values have the potential to detect F1 from
F0.
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