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Abstract #3016

Assessment of aquaporins function in stages of clinical liver fibrosis using multi-b DWI

Qiuju Li 1 , Qiyong Guo 1 , Zhoushe Zhao 2 , Jiahui Li 1 , Bing Yu 1 , and Yu Shi 1

1 Radiology, shengjing hospital, Shenyang, Liaoning, China, 2 General Electronic Company Healthcare (China), General Electronic Company Healthcare (China), Beijing, Beijing, China

A multi-b DWI was to investigate the value of aquaporins function in diagnosis of early liver fibrosis in patients. At low-b values, the resulted ADCs reflected the hepatic blood perfusion information while the functional changes of the AQPs on cell membranes at high b values. The "standard" ADC value obtained by conventional method and low-b, mid-b and high-b ADC value mesured by tri-exponential model all can distinguish normal from cirrhosis of the liver tissue. The "standard" ADC value can be hardly used to grade early liver fibrosis. However, both low-b values and high-b ADC values have the potential to detect F1 from F0.

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