Abstract #3017
Surface to Volume ratio mapping of mouse GBM using OGSE
Olivier Reynaud 1,2 , Kerryanne V Winters 1,2 , Dmitry S Novikov 1,2 , and Sungheon Gene Kim 1,2
1
Center for Advanced Imaging Innovation and
Research (CAI2R), Department of Radiology, New York
University School of Medicine, New York, NY, United
States,
2
Bernard and Irene Schwartz Center for
Biomedical Imaging, Department of Radiology, New York
University School of Medicine, New York, NY, United
States
In this study we show that the surface to volume ratio
(S/V) is a natural candidate to study in vivo the
restrictions in glioblastoma in the very short diffusion
time regime. OGSE-DWI data acquired on preclinical
scanners (G<760 mT/m, frequency in range [60-225] Hz)
demonstrates excellent agreement with Mitra regime
(linear fit of ADC vs square-root of diffusion time:
R2=0.95) inside the tumor (N=13), suggesting that S/V
can be derived in a robust manner. S/V correlates
partially with ADC calculated with PGSE (Spearman
coefficient -0.43). Both metrics sense different scales
and provide complementary information regarding tumor
growth, treatment or microstructure.
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