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Abstract #3017

Surface to Volume ratio mapping of mouse GBM using OGSE

Olivier Reynaud 1,2 , Kerryanne V Winters 1,2 , Dmitry S Novikov 1,2 , and Sungheon Gene Kim 1,2

1 Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, NY, United States, 2 Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, United States

In this study we show that the surface to volume ratio (S/V) is a natural candidate to study in vivo the restrictions in glioblastoma in the very short diffusion time regime. OGSE-DWI data acquired on preclinical scanners (G<760 mT/m, frequency in range [60-225] Hz) demonstrates excellent agreement with Mitra regime (linear fit of ADC vs square-root of diffusion time: R2=0.95) inside the tumor (N=13), suggesting that S/V can be derived in a robust manner. S/V correlates partially with ADC calculated with PGSE (Spearman coefficient -0.43). Both metrics sense different scales and provide complementary information regarding tumor growth, treatment or microstructure.

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