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Abstract #3019

A Simplified Intravoxel Incoherent Motion Model for Diffusion Weighted Imaging in Prostate Cancer Evaluation: Comparison with Monoexponential and Biexponential Models

Qing Yuan 1 , Daniel N Costa 1,2 , Julien Sngas 3 , Yin Xi 1 , Andrea J Wiethoff 2,4 , Robert E Lenkinski 1,2 , and Ivan Pedrosa 1,2

1 Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 2 Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 3 Philips Research Laboratories, Hamburg, Germany, 4 Philips Research North America, Briarcliff Manor, New York, United States

The purpose of this study was to compare a simplified IVIM (sIVIM) model with commonly used monoexponential and biexponential models in diffusion characterization of prostate cancer and noncancerous prostate tissues. The sIVIM approach models the perfusion effect with a Delta function at b=0 s/mm2, which allows assessment of true tissue diffusion with fewer b-values therefore reducing scan time. Our results demonstrated that the sIVIM model provided ADC estimates in prostate cancer and noncancerous prostate tissues in central gland and peripheral zone equivalent to the biexponential model, and it showed better correlation with tumor aggressiveness than the monoexponential model.

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