Abstract #3022
Intravoxel incoherent motion MR imaging: diffusion and perfusion characteristics in early assessment of chemotherapy response in nasopharyngeal carcinoma
Zhuangzhen He 1 , Yunbin Chen 1 , Youping Xiao 1 , Minfeng Li 1 , Weibo Chen 2 , and He Wang 3
1
Fujian Province Cancer Hospital, Fuzhou,
Fujian, China,
2
Philips
Healthcare, Shanghai, China,
3
Philips
Research China, Shanghai, China
IVIM MR imaging was conducted on untreated NPC cases
during two cycle of induction chemotherapy. The
diffusion and perfusion characteristics D, D*and f were
derived and the alterations of maximum tumor diameter
were measured. We found D ascended continually with the
earliest significant rise at day 3 while D* fluctuated
momentarily at the first cycle. Patients was considered
responders and non-responders referring to the RECIST
criteria after chemotherapy. D and f of responders
showed a higher tendency than non-responders. IVIM is
feasible in detecting early diffusion and perfusion
response to chemotherapy in NPC and potentially helpful
with prognosis determination.
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