Characterizing the diffusion properties of blood

Aim of this work was to measure the diffusion coefficient of human blood samples dependent on diffusion time T and diffusion gradient profile. A phantom is presented which allows one to maintain the sample temperature and to prevent the blood cells from sedimentation. Measured ADCs decrease with increasing T for the flow-compensated gradient profile and stabilize on a lower level in the bipolar case. The effects can be explained considering blood as a multi-compartment system. Differences between individual blood samples are, however, large compared to these variations. IVIM applications might benefit from individually measured diffusion coefficients of blood.

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