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Abstract #3028

How to get more out of a clinically feasible 64 Gradient dMRI Acquisition: Multi-Shell versus Single-Shell

Rutger Fick 1 , Mauro Zucchelli 2 , Gabriel Girard 1,3 , Gloria Menegaz 2 , Maxime Descoteaux 3 , and Rachid Deriche 1

1 Team Athena - INRIA, Sophia Antipolis, Alpes Maritimes, France, 2 University of Verona, Verona, Italy, 3 Sherbrooke Connectivity Imaging Lab (SCIL), Computer Science Department, Quebec, Canada

In clinical applications for diffusion MRI the maximum number of samples is often limited by practical constraints. Given a clinically feasible 64 direction acquisition, we compare the single-shell approach, which samples at a single b-value, with a multi-shell approach, which spreads the same number of samples over multiple b-values. We show that using the continuous analytical bases 3D-SHORE and MAP-MRI on multi-shell data we can have a better estimation of both the white matter directionality using the ODF, and microstructural features such as the axon radius, without increasing the number of samples.

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