Model-based estimation of microstructure parameters from diffusion MRI data in a substrate with microscopic anisotropy and a distribution of pore sizes

Current methods of calculating microscopic anisotropy lack specificity in the case of substrates with a distribution of pore sizes. Here we present for the first time a model-based approach for estimating explicit microstructural features, such as pore size and elongation that are invariant to size distribution. Single pulsed field gradient (PFG) measurements are not sufficient to recover this information, while double and triple PFG measurements yield accurate estimates for all the substrates considered in the simulation.

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