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Abstract #3040

Human brain tissue microstructure characterization using 3D-SHORE on the HCP data

Mauro Zucchelli 1 , Maxime Descoteaux 2 , and Gloria Menegaz 1

1 Computer Science, University Of Verona, Verona, Verona, Italy, 2 Sherbrooke Connectivity Imaging Lab (SCIL), Universit de Sherbrooke, Sherbrooke, Quebec, Canada

The Human Connectome Project (HCP) high resolution data represents the state of the art for diffusion imaging in human brain. 3D-SHORE is an analytical basis for diffusion MRI which is able to reconstruct the Ensemble Average Propagator (EAP) from multi-shell data for the characterization of the diffusion process in each voxel. In this work we calculated the analytical expressions for the recently introduced EAP-derived microstructural indices including RTOP, RTAP and RTPP for 3D-SHORE model. The use of the HCP data in combination with these biomarkers provides an estimation of microstructural changes between the different brain tissues.

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