Abstract #3041
Micro-MR correlates of cellular-level alterations in epileptogenesis
Katharina Gbel 1 , Johannes Gerlach 2 , Robert Kamberger 3 , Jochen Leupold 1 , Dominik von Elverfeldt 1 , Carola Haas 2 , Jan G. Korvink 3 , Jrgen Hennig 1 , and Pierre LeVan 1
1
Medical Physics, Dept. of Radiology,
University Medical Center Freiburg, Freiburg, Germany,
2
Experimental
Epilepsy Research, University Medical Center Freiburg,
Freiburg, Germany,
3
Dept.
of Microsystems Engineering (IMTEK), Technical Faculty,
University of Freiburg, Freiburg, Germany
Organotypic hippocampal slice cultures are a well
established neuronal culture system that combines the
advantages of cell culturing with a neuronal network
tightly reflecting the in vivo state. Our aim is to
investigate these changes during epileptogenesis using
high spatial resolution MR microscopy, whose non
invasiveness allows continuous longitudinal monitoring.
GRE and EPI-DTI sequence protocols were adapted in order
to resolve hippocampal cytoarchitecture and connectivity
patterns of epileptic and healthy tissue and a
correspondence was established with immunohistochemical
changes. This provides deeper insights into the dynamic
processes of epileptogenesis at the cellular level in in
vitro preparations.
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