Abstract #3042
Microscopic anisotropy in the fixed spinal cord from dPFG and qMAS diffusion weighted imaging compared to DTI
Nathan P Skinner 1,2 and Matthew D Budde 1,3
1
Biophysics Graduate Program, Medical College
of Wisconsin, Milwaukee, WI, United States,
2
Medical
Scientist Training Program, Medical College of
Wisconsin, Milwaukee, WI, United States,
3
Department
of Neurosurgery, Medical College of Wisconsin,
Milwaukee, WI, United States
Recently proposed double pulsed field gradient and
q-vector magic angle spinning techniques aim to
circumvent limitations of diffusion tensor imaging in
resolving tissue microstructure. We applied these
sequences to fixed spinal cord and compared derived
microstructure measurements to diffusion tensor
parameters obtained from conventional pulsed gradient
spin echo images. Fractional eccentricity and
microscopic fractional anisotropy parameters derived
with these techniques exhibit less difference between
gray and white matter anisotropy along with reduced
interference from fiber crossing in the cord compared to
standard fractional anisotropy. Thus, improved
microstructure determination combined with greater
efficiency of these sequences warrants consideration for
future applications.
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