Estimation of Intra-Axonal Fraction in Spinal Cord White Matter by using Monte Carlo Simulation of Water Diffusion and High b-value Diffusion Sensitized MRI
Nabraj Sapkota 1,2 , John Rose 3 , Scott Miller 4 , Beth Bowman 4 , Lubdha Shah 4 , Erica Bisson 5 , Sook Yoon 1,6 , and Eun-Kee Jeong 1,7
Utah Center for Advanced Imaging Research,
University of Utah, SLC, UT, United States,
of Physics, University of Utah, SLC, UT, United States,
of Neurology, University of Utah, SLC, UT, United
of Radiology, University of Utah, SLC, UT, United
of Neurosurgery, University of Utah, SLC, UT, United
of Multimedia Engineering, Mokpo National Engineering,
of Radiology, Korea University, Seoul, Korea
By using diffusion sensitized imaging (DSI), the
intra-cellular fraction (ICF) has been reported as
20-30% and is considered as a non-expected fraction.
Since extra-cellular fraction has been reported as
20-30% in the brain, it has been expected 70 80% of
ICF which is not true in white matter where myelin
occupied large fraction. Using the Monte Carlo
simulation (MCS) and DSI measurement, we estimate
intra-axonal fraction in cervical spinal cord (CSC)
white matter. The DSI measurement estimated 41% of the
contribution from intra-axonal space in pig CSC, which
fairly agrees with light microscopy result.
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