Abstract #3045
Diffusion MRI detects early axon loss despite confounding inflammation in optic neuritis
Carlos J Perez-Torres 1 , Tsen-Hsuan Lin 1 , Chia-Wen Chiang 1 , Peng Sun 1 , Yong Wang 1,2 , Anne H Cross 2,3 , and Sheng-Kwei Song 1,2
1
Radiology, Washington University, Saint
Louis, MO, United States,
2
Hope
Center for Neurological Disorders, Washington
University, Saint Louis, MO, United States,
3
Neurology,
Washington University, Saint Louis, MO, United States
Atrophy assessed by structural MRI is a common image
marker of axon/neuron loss in CNS diseases. However,
atrophy can be underestimated by confounding increase in
tissue volume resulting from elevated cellularity and
edema resulting from inflammation. With diffusion basis
spectrum imaging, we can quantify an axon volume which
is a combination of the percent of signal associated
with fibers and optic nerve volume, removing non-fiber
partial volume effect. This axon volume detected axon
loss in the presence of confounding inflammation at the
onset of optic neuritis in the experimental autoimmune
encephalomyelitis (EAE) mouse model.
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