Assessment and Prediction of Vestibular Schwannoma Response to Anti-angiogenic Therapy in Neurofibromatosis Type 2 Patient Using Low Dose High Temporal Resolution DCE-MRI

Clinical DTR-DCE data were collected from 12 patients with NF2 receiving anti-angiogenic therapy for rapidly growing vestibular schwannoma, to test potential of the pre-bolus low (1/5 of full) dose high temporal resolution (LDHT)-DCE-MRI. Pharmacokinetic parameters from LDHT and the major full dose high spatial resolution (FDHS) were jointly used as predictors to identify responders, who might benefit from the treatment. Results showed better separation of intra- and extra vascular space in brain on LDHT derived images than FDHS. The use of pre-bolus LDHT improved both assessment and prediction of vestibular schwannoma response to anti-angiogenic therapy in neurofibromatosis type 2 patients.

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