Abstract #3049
Assessment and Prediction of Vestibular Schwannoma Response to Anti-angiogenic Therapy in Neurofibromatosis Type 2 Patient Using Low Dose High Temporal Resolution DCE-MRI
Ka-Loh Li 1 , Alan Jackson 1 , and Xiaoping Zhu 1
1
WMIC, University of Manchester, Manchester,
Great Manchester, United Kingdom
Clinical DTR-DCE data were collected from 12 patients
with NF2 receiving anti-angiogenic therapy for rapidly
growing vestibular schwannoma, to test potential of the
pre-bolus low (1/5 of full) dose high temporal
resolution (LDHT)-DCE-MRI. Pharmacokinetic parameters
from LDHT and the major full dose high spatial
resolution (FDHS) were jointly used as predictors to
identify responders, who might benefit from the
treatment. Results showed better separation of intra-
and extra vascular space in brain on LDHT derived images
than FDHS. The use of pre-bolus LDHT improved both
assessment and prediction of vestibular schwannoma
response to anti-angiogenic therapy in neurofibromatosis
type 2 patients.
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