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Abstract #3058

Retrospective Resolution Adaption for DCE MRI Using 3D Golden Angle Radial Acquisition

Ina Nora Kompan 1,2 , Benjamin Richard Knowles 3 , Cristoffer Cordes 1 , and Matthias Guenther 1,2

1 Fraunhofer MEVIS, Bremen, Bremen, Germany, 2 mediri GmbH, Heidelberg, Baden-Wrttemberg, Germany, 3 Universittsklinikum Freiburg, Freiburg, Baden-Wrttemberg, Germany

In dynamic contrast-enhanced MRI, pharmacokinetic modeling is used to quantify tissue physiology. The maximal allowed spatial resolution to still guarantee accurate model fitting depends on the shape of the signal time curve S(t), which is not a priori known. In this work, a 3D golden angle (GA) radial sequence is used to retrospectively adapt spatial resolutions to S(t) throughout the time interval to achieve the maximal feasible spatial resolutions. Using a perfusion phantom, it is shown that, compared to a high temporal and low spatial resolution sequence, the spatial resolution of parameter maps is improved at the same fitting accuracy.

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