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Abstract #3059

Comparison of different leakage-correction methods for DSC-based CBV measurement in human gliomas

Anne Kluge 1 , Mathias Lukas 2 , Vivien Toth 3 , Stefan Frster 2 , Claus Zimmer 1 , and Christine Preibisch 1,4

1 Department of Neuroradiology, Klinikum rechts der Isar, TU Mnchen, Munich, Germany, 2 Department of Nuclear Medicine, Klinikum rechts der Isar, TU Mnchen, Munich, Germany, 3 Department of Radiology, Klinikum rechts der Isar, TU Mnchen, Munich, Germany, 4 Department of Neurology, Klinikum rechts der Isar, TU Mnchen, Munich, Germany

Aim of this study was to investigate the influence of contrast agent leakage on relative CBV, using clinical scanning protocols. Three post-processing methods were compared, concerning CBV and K2 (permeability parameter) for data acquired with and without pre-bolus. Because of tumor heterogeneity CBV was separately analyzed for T1 (K2>0) and T2* (K2<0) effects. Generally all methods increased CBV for T1 and decreased CBV for T2* effects, but differently pronounced. Future investigations should combine the advantages of each method to improve CBV estimation.

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