Abstract #3059
Comparison of different leakage-correction methods for DSC-based CBV measurement in human gliomas
Anne Kluge 1 , Mathias Lukas 2 , Vivien Toth 3 , Stefan Frster 2 , Claus Zimmer 1 , and Christine Preibisch 1,4
1
Department of Neuroradiology, Klinikum
rechts der Isar, TU Mnchen, Munich, Germany,
2
Department
of Nuclear Medicine, Klinikum rechts der Isar, TU
Mnchen, Munich, Germany,
3
Department
of Radiology, Klinikum rechts der Isar, TU Mnchen,
Munich, Germany,
4
Department
of Neurology, Klinikum rechts der Isar, TU Mnchen,
Munich, Germany
Aim of this study was to investigate the influence of
contrast agent leakage on relative CBV, using clinical
scanning protocols. Three post-processing methods were
compared, concerning CBV and K2 (permeability parameter)
for data acquired with and without pre-bolus. Because of
tumor heterogeneity CBV was separately analyzed for T1
(K2>0) and T2* (K2<0) effects. Generally all methods
increased CBV for T1 and decreased CBV for T2* effects,
but differently pronounced. Future investigations should
combine the advantages of each method to improve CBV
estimation.
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