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Abstract #3060

Closing up on pharmacokinetic modeling Exploring the limits of the Tofts model for DCE-MRI analysis using intravital microscopy

Dina Sikpa 1 , Rjean Lebel 1 , Vincent Turgeon 1 , Lisa Whittingstall 1 , Jrmie Fouquet 1 , Marc-Andr Bonin 1 , Luc Tremblay 1 , and Martin Lepage 1

1 Centre d'imagerie molculaire de Sherbrooke, Universit de Sherbrooke, Sherbrooke, Qubec, Canada

The Tofts model is commonly used to parameterize tissue perfusion, vessel permeability, extracellular extravascular space and vascular volume. However, these quantities are difficult to confirm independently. Here, we propose using intravital microscopy to monitor the extravasation of a fluorescent contrast agent, and its accumulation in the cortex of live animals. We compare our fluorescence imaging measurements with classic DCE-MRI pharmacokinetic modeling results.

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