Closing up on pharmacokinetic modeling Exploring the limits of the Tofts model for DCE-MRI analysis using intravital microscopy
Dina Sikpa 1 , Rjean Lebel 1 , Vincent Turgeon 1 , Lisa Whittingstall 1 , Jrmie Fouquet 1 , Marc-Andr Bonin 1 , Luc Tremblay 1 , and Martin Lepage 1
Centre d'imagerie molculaire de Sherbrooke,
Universit de Sherbrooke, Sherbrooke, Qubec, Canada
The Tofts model is commonly used to parameterize tissue
perfusion, vessel permeability, extracellular
extravascular space and vascular volume. However, these
quantities are difficult to confirm independently. Here,
we propose using intravital microscopy to monitor the
extravasation of a fluorescent contrast agent, and its
accumulation in the cortex of live animals. We compare
our fluorescence imaging measurements with classic
DCE-MRI pharmacokinetic modeling results.
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