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Abstract #3061

Quantifying pulmonary perfusion in health and pulmonary disease with DCE-MRI: effect of bolus delay

J. Tim Marcus 1 , Barry Ruijter 1 , Taco Kind 2 , Rudolf Verdaasdonk 1 , and Anton Vonk Noordegraaf 2

1 Physics & Medical Technology, VU University Medical Center, Amsterdam, Netherlands, 2 Pulmonology, VU University Medical Center, Amsterdam, Netherlands

The aim of this study is to explore the effect of the delay between arterial input function and lung tissue enhancement curve on the observed pulmonary blood flow. 3D dynamic contrast-enhanced MRI was applied in healthy control subjects (n=5), and patients with pulmonary hypertension (n=14) or pulmonary artery atresia (n=5). Median bolus delay time ranged from 1.5 s for healthy subjects to 3.0 s for pulmonary hypertension patients. Not correcting for delay resulted in an average Pulmonary Blood Flow underestimation of 47 percent. Thus, correction for bolus delay is essential for accurate estimation of pulmonary perfusion parameters.

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