Abstract #3063
A tracer kinetic model with optimal compartments for assessing intravoxel tumor heterogeneity in papillary thyroid carcinoma
Yonggang Lu 1 , Yousef Mazaheri 1 , Vaois Hatzoglou 1 , Hilda Stambuk 1 , Ashok Shaha 1 , Joseph O. Deasy 1 , R. Michael Tuttle 1 , and Amita Shukla-Dave 1
1
Memorial Sloan-Kettering Cancer Center, NEW
YORK, New York, United States
Intravoxel microvascular kinetics heterogeneity is not
addressed by the commonly used tracer kinetic model (the
Toftss model) in dynamic contrast enhanced magnetic
resonance imaging (DCE-MRI). In this study, we present a
modified tracer capillary-tissue exchange model with
multiple compartments (oCXM). The model was evaluated on
DCE-MRI data collected retrospectively from 7 patients
with biopsy proven papillary thyroid carcinoma (PTC).
The results demonstrate that the oCXM outperforms the
Toftss model in characterizing contrast kinetics,
providing a more comprehensive interpretation of tumor
kinetics. Once validated, this model could provide
additional imaging biomarkers for assessing tumor
characteristics including tumor aggressiveness.
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