Meeting Banner
Abstract #3063

A tracer kinetic model with optimal compartments for assessing intravoxel tumor heterogeneity in papillary thyroid carcinoma

Yonggang Lu 1 , Yousef Mazaheri 1 , Vaois Hatzoglou 1 , Hilda Stambuk 1 , Ashok Shaha 1 , Joseph O. Deasy 1 , R. Michael Tuttle 1 , and Amita Shukla-Dave 1

1 Memorial Sloan-Kettering Cancer Center, NEW YORK, New York, United States

Intravoxel microvascular kinetics heterogeneity is not addressed by the commonly used tracer kinetic model (the Toftss model) in dynamic contrast enhanced magnetic resonance imaging (DCE-MRI). In this study, we present a modified tracer capillary-tissue exchange model with multiple compartments (oCXM). The model was evaluated on DCE-MRI data collected retrospectively from 7 patients with biopsy proven papillary thyroid carcinoma (PTC). The results demonstrate that the oCXM outperforms the Toftss model in characterizing contrast kinetics, providing a more comprehensive interpretation of tumor kinetics. Once validated, this model could provide additional imaging biomarkers for assessing tumor characteristics including tumor aggressiveness.

This abstract and the presentation materials are available to members only; a login is required.

Join Here