Abstract #3064
An Efficient Method for Pharmacokinetics Parameter Calculation in Permeability Study Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging
Chunhao Wang 1,2 , Fang-Fang Yin 1,2 , and Zheng Chang 1,2
1
Radiation Oncology, Duke University Medical
Center, Durham, North Carolina, United States,
2
Medical
Physics Graduate Program, Duke University, Durham, North
Carolina, United States
This work proposed an efficient method that can
accelerate the pharmacokinetics parameter calculation in
the T1w dynamic contrast enhanced MRI (DCE-MRI)
permeability study with high temporal resolution. The
results of the simulation studies in this work indicated
that when comparing with the currently used calculation
methods, the proposed calculation methods achieved
comparable or improved calculation accuracies with
considerably improved calculation efficiency.
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