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Abstract #3064

An Efficient Method for Pharmacokinetics Parameter Calculation in Permeability Study Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging

Chunhao Wang 1,2 , Fang-Fang Yin 1,2 , and Zheng Chang 1,2

1 Radiation Oncology, Duke University Medical Center, Durham, North Carolina, United States, 2 Medical Physics Graduate Program, Duke University, Durham, North Carolina, United States

This work proposed an efficient method that can accelerate the pharmacokinetics parameter calculation in the T1w dynamic contrast enhanced MRI (DCE-MRI) permeability study with high temporal resolution. The results of the simulation studies in this work indicated that when comparing with the currently used calculation methods, the proposed calculation methods achieved comparable or improved calculation accuracies with considerably improved calculation efficiency.

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