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Abstract #3065

Comparison of the arterial input function measured at low and high contrast agent doses in prostate cancer patients

Shiyang Wang 1 , Gregory S. Karczmar 1 , Xiaobing Fan 1 , Federico Pineda 1 , Milica Medved 1 , Ambereen Yousuf 1 , and Aytek Oto 1

1 Radiology, University of Chicago, Chicago, IL, United States

To assess shutter speed and T2* effects on AIF, we compared AIF_LD, measured following a low contrast dose (0.015 mmol/kg), to AID_HD, measured following a high dose (0.085 mmol/kg), from DCE-MRI scans of prostate cancer patients. A new empirical mathematical model for AIF_LD is introduced. The amplitude of AIF_LD, normalized by dose, was 6.45 times larger than that of AIF_HD. The shapes of AIF_LD and AIF_HD were substantially different: the first pass peak was absent from AIF_HD in all cases, and a second pass peak was typically detected in AIF_LD but not in AIF_HD.

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