Abstract #3065
Comparison of the arterial input function measured at low and high contrast agent doses in prostate cancer patients
Shiyang Wang 1 , Gregory S. Karczmar 1 , Xiaobing Fan 1 , Federico Pineda 1 , Milica Medved 1 , Ambereen Yousuf 1 , and Aytek Oto 1
1
Radiology, University of Chicago, Chicago,
IL, United States
To assess shutter speed and T2* effects on AIF, we
compared AIF_LD, measured following a low contrast dose
(0.015 mmol/kg), to AID_HD, measured following a high
dose (0.085 mmol/kg), from DCE-MRI scans of prostate
cancer patients. A new empirical mathematical model for
AIF_LD is introduced. The amplitude of AIF_LD,
normalized by dose, was 6.45 times larger than that of
AIF_HD. The shapes of AIF_LD and AIF_HD were
substantially different: the first pass peak was absent
from AIF_HD in all cases, and a second pass peak was
typically detected in AIF_LD but not in AIF_HD.
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