Abstract #3194
Robust Tissue Segmentation of Human Brain Images Acquired with a Surface Coil at Ultrahigh Field
Byeong-Yeul Lee 1 , Wei Chen 1 , and Xiao-Hong Zhu 1
1
Center for Magnetic Resonance Research,
Department of Radiology, University of Minnesota,
Minneapolis, MN, United States
Surface coil has been commonly employed in human brain
MRI and in vivo MRS research since it offers the best
attainable signal-to-noise ratio (SNR) in the brain
region of interest. However, quantitative tissue
segmentation becomes a challenging task due to the
inhomogeneous B1 field of the surface coil, which leads
to large variation in the MR signal and image contrast.
In this study, we implemented and tested an automatic
brain tissue segmentation method including bias field
correction and partial volume estimation (PVE) to
reliably quantify tissue contents and distributions in
the brain region covered by a surface coil at 7T. The
results indicate that this segmentation method is robust
for differentiating various brain tissues; and the CSF
volume can be more accurately estimated by PVE with
model parameters as compared to one without
optimization. Therefore, this advanced segmentation
method will provide a robust and valuable tool for many
quantitative brain MRI/MRS studied, and it is
particularly critical for ultrahigh-field applications
using either a surface coil or transmit-receive array
coil or even head volume coil. In all these cases, an
inhomogeneous B1 distribution is present in the human
head owing to the complication of the RF wave behavior
at high/ultrahigh fields.
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