Abstract #3196
A Parkinson's disease 31 P-MRSI study at 7T
Silvina G Horovitz 1 , Peter Lauro 2 , Pascal Sati 3 , Nora Vanegas-Arroyave 2 , Codrin I Lungu 2 , and Mark Hallett 1
1
MNB, HMCS, NINDS, NIH, Bethesda, MD, United
States,
2
OCD,
NINDS, NIH, Bethesda, MD, United States,
3
NIB,
TNU, NINDS, NIH, Bethesda, MD, United States
One of the pathological changes in Parkinsons Disease
(PD) is the loss of dopaminergic neurons in the
substantia nigra (SN), believed to be related to
impaired mitochondrial function. We scanned healthy
volunteers, Parkinsons disease patients and patients
with early parkinsonism presentation at 7T. We studied
energy and phospholipid metabolism by exploring the
stability of the data, and the effects of group, when
accounting for age and sex on these measures. Taking
into account sex and age, we find significant group
differences. 31P-MRSI might become a useful tool for the
differential diagnosis of Parkinsons disease.
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