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Abstract #3196

A Parkinson's disease 31 P-MRSI study at 7T

Silvina G Horovitz 1 , Peter Lauro 2 , Pascal Sati 3 , Nora Vanegas-Arroyave 2 , Codrin I Lungu 2 , and Mark Hallett 1

1 MNB, HMCS, NINDS, NIH, Bethesda, MD, United States, 2 OCD, NINDS, NIH, Bethesda, MD, United States, 3 NIB, TNU, NINDS, NIH, Bethesda, MD, United States

One of the pathological changes in Parkinsons Disease (PD) is the loss of dopaminergic neurons in the substantia nigra (SN), believed to be related to impaired mitochondrial function. We scanned healthy volunteers, Parkinsons disease patients and patients with early parkinsonism presentation at 7T. We studied energy and phospholipid metabolism by exploring the stability of the data, and the effects of group, when accounting for age and sex on these measures. Taking into account sex and age, we find significant group differences. 31P-MRSI might become a useful tool for the differential diagnosis of Parkinsons disease.

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