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Abstract #3199

Simultaneous T 1 and T 2 quantitation of the Human Brain at 7 Tesla by MR Fingerprinting

Yun Jiang 1 , Huihui Ye 2,3 , Berkin Bilgic 2 , Dan Ma 1 , Thomas Witzel 2 , Stephen F. Cauley 2 , Elfar Adalsteinsson 2,4 , Kawin Setsompop 2 , Mark A. Griswold 1,5 , and Lawrence L. Wald 2,4

1 Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, United States, 2 Department of Radiology, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, United States, 3 Department of Biomedical Engineering, Zhejiang University, Hangzhou, Zhejiang, United States, 4 Department of Electrical Engineering and Computer Science; Harvard-MIT Division of Health Sciences, MIT, Cambridge, Massachusetts, United States, 5 Department of Radiology, Case Western Reserve University, Ohio, United States

The MRF method has been shown to be extremely efficient in the quantitation of relaxation parameters. In this study we used an MRF method based on the Fast-Imaging with Steady-state free Precession (FISP) type sequence to quantify T1, T2 and proton density at 7 T. A voxel specific dictionary was calculated based on B1+ inhomogeneity estimated via an AFI scan. A template-matching algorithm was used to extract T1 and T2 values by matching a dictionary entry to the acquired signal evolution. With additional B1 measurement time, MRF method is able to quantify T1 and T2 values within one minute per slice.

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