Wide screen visual stimulation: fMRI combined with fast GABA detection

Functional MRI combined with functional MRS of visual cortex can relate BOLD signals to neuronal metabolism. However, functional MRS, particularly for GABA, is limited by SNR. By increasing the limited visual field of view, a larger spatial extend of activation will be obtained. Therefore, by increasing the voxel that encompasses tissue that is uniformly active, GABA signals can be obtained at high temporal resolution . Here, we examine the effectiveness of using a half volume transmit coil with a large screen for visual stimulation, in terms of extent of activation in primary visual cortex and in terms of achievable voxel size for GABA measurements in the same region.

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