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Abstract #3243

Measurement and theoretical description of spin-echo T2 anisotropy in the human brain

Michael John Knight 1 , Bryony Wood 1 , Elizabeth Coulthard 2 , and Risto Kauppinen 1

1 School of experimental psychology, University of Bristol, Bristol, Avon, United Kingdom, 2 Southmead Hospital, University of Bristol, Bristol, Avon, United Kingdom

Magnetic resonance relaxation parameters are highly sensitive to the microstructure and biochemistry of tissues. We show here that spin-echo T2 can be related to fiber orientation and potentially myelin-associated water fraction through measurements of its anisotropy in the human brain. We also propose a novel model for nuclear spin relaxation anisotropy which we validate with data from human volunteers. Such measurements may be used to provide a more detailed and objective assessment of tissue state than is apparent by visual inspection of images.

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