Abstract #3243
Measurement and theoretical description of spin-echo T2 anisotropy in the human brain
Michael John Knight 1 , Bryony Wood 1 , Elizabeth Coulthard 2 , and Risto Kauppinen 1
1
School of experimental psychology,
University of Bristol, Bristol, Avon, United Kingdom,
2
Southmead
Hospital, University of Bristol, Bristol, Avon, United
Kingdom
Magnetic resonance relaxation parameters are highly
sensitive to the microstructure and biochemistry of
tissues. We show here that spin-echo T2 can be related
to fiber orientation and potentially myelin-associated
water fraction through measurements of its anisotropy in
the human brain. We also propose a novel model for
nuclear spin relaxation anisotropy which we validate
with data from human volunteers. Such measurements may
be used to provide a more detailed and objective
assessment of tissue state than is apparent by visual
inspection of images.
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