Abstract #3244
Differentiating microscopic field inhomogeneity induced relaxation from R 2 and R 2 * relaxations with magnetic field correlation imaging
Chu-Yu Lee 1,2 , Xingju Nie 1,2 , Jens H Jensen 1,2 , Vitria Adisetiyo 1,2 , Qingwei Liu 3 , and Joseph A Helpern 1,2
1
Department of Radiology and Radiology
Science, Medical University of South Carolina,
Charleston, SC, United States,
2
Center
for Biomedical Imaging, Medical University of South
Carolina, Charleston, SC, United States,
3
Neuroimaging
research, Barrow Neurological Institute, Phoenix, AZ,
United States
In biological tissues, the presence of iron-rich cells,
deoxygenated red blood cells or a paramagnetic agent
generates micron-scale variations of magnetic
susceptibility, resulting in microscopic magnetic field
inhomogeneities (μMFI). Therefore, it is possible to
characterize in vivo tissue properties through
quantifying the μMFI. The relaxation rates R2, R2*, and
R2′ have been previously used to quantify the relaxation
due to μMFI. An alternative approach is magnetic field
correlation (MFC) imaging, where the measured MFC is
closely linked to the μMFI. MFC has been shown to
effectively reflect iron depositions in the brain during
normal aging and disease processes. A prior study
compared MFC, R2, and R2* for cell suspensions with
different Gadolinium (Gd) contrast agent concentrations.
However, the distinction between these measures has not
been investigated with structure-induced variable μMFI.
In this work, we investigate how MFC, R2, R2*, R2′
change in phantoms with distinct μMFI properties.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
