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Abstract #3250

Variable Flip Angle T1 Mapping in the Human Brain with Reduced T2 Sensitivity Using Fast RF-Spoiled Gradient Echo Imaging

Rahel Heule 1 , Carl Ganter 2 , and Oliver Bieri 1

1 Division of Radiological Physics, Department of Radiology, University of Basel Hospital, Basel, Switzerland, 2 Department of Radiology, Klinikum rechts der Isar, Technische Universitt Mnchen, Munich, Germany

Many T 1 mapping methods have been developed, however, they deliver substantially varying quantification results for the same tissues and at equal field strength. The variable flip angle (VFA) method based on radiofrequency spoiled gradient echo imaging provides 3D MR data sets and allows for volumetric T 1 mapping in clinically feasible times. In this work, a new postprocessing approach is proposed to overcome the T 2 -related bias originating from incomplete spoiling in conventional VFA T 1 quantification. Excellent agreement with inversion recovery reference measurements was obtained in vivo for human brain tissues demonstrating the potential of the new method to provide accurate whole-brain T 1 quantification at high-resolution.

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