Fast and robust 3D T1 mapping using spiral gradient shape and continuous radio-frequency excitation at 7 T : Application on cardiac Manganese Enhanced MRI (MEMRI) in mice

In this study, a fast 3D T1 mapping method using stack-of-spirals sampling scheme and continuous radio-frequency pulse excitation at high magnetic field is presented. This sequence with a new fitting method has been validated to detect variations of Manganese concentrations in vivo and in vitro on both healthy and pathological mice models. Combining this method with a manganese injection allowed to accurately characterize tissue damages induced by a myocardial infarction.

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