Meeting Banner
Abstract #3258

R2* estimation performance in iron-overloaded livers: fit first or average first?

Debra E. Horng 1,2 , Diego Hernando 1 , and Scott B. Reeder 1,2

1 Radiology, University of Wisconsin-Madison, Madison, WI, United States, 2 Medical Physics, University of Wisconsin-Madison, Madison, WI, United States

R2*-based measurement of liver iron is appealing due to its rapid acquisition and its linear relationship with iron concentration. Estimation techniques generally fall into two main categories: "fit-first" (FF), where an R2* map is generated at each voxel, followed by region-of-interest (ROI) averaging, and "average-first" (AF) techniques, where the signal is averaged over an ROI, followed by fitting an R2* estimate. We examine the relative performance of 6 techniques in simulations and phantoms over 50s -1 to 2000s -1 . The combination of high R2* and low SNR leads to poor performance in the phantom, likely requiring higher SNR/shorter TEs for accurate R2* relaxometry.

This abstract and the presentation materials are available to members only; a login is required.

Join Here