MRI properties of cerebrospinal fluid for assessment in neurodegenerative diseases

There continues to be interest in using changes in CSF properties to image neurodegenerative diseases. To optimize MRI sequences that enable segmentation of CSF from tissue, we characterized the CSF relaxometric properties at various field strengths in vivo and in vitro. We have shown an important difference of in vitro CSF T2 vs saline T2 that is not explained with CSF metals. Proteins or lipids could influence CSF T2. Our in vitro results suggest that in vivo T2 value at high field is incorrect and that low field is more optimal to quantify CSF relaxivity in vivo.

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