MRI properties of cerebrospinal fluid for assessment in neurodegenerative diseases
Alexia Daoust 1 , Stephen Dodd 1 , Govind Nair 1 , Steven Jacobson 1 , Daniel S. Reich 1 , and Alan Koretsky 1
NINDS, LFMI, NIH, Bethesda, MD, United
There continues to be interest in using changes in CSF
properties to image neurodegenerative diseases. To
optimize MRI sequences that enable segmentation of CSF
from tissue, we characterized the CSF relaxometric
properties at various field strengths in vivo and in
vitro. We have shown an important difference of in vitro
CSF T2 vs saline T2 that is not explained with CSF
metals. Proteins or lipids could influence CSF T2. Our
in vitro results suggest that in vivo T2 value at high
field is incorrect and that low field is more optimal to
quantify CSF relaxivity in vivo.
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