Abstract #3267
Blood serum demonstrates antioxidative mechanism: a Magnetic Resonance Relaxation Studies
Lech Wiktor Skorski 1 , Dorota Wierzuchowska 2 , and Barbara Blicharska 1
1
Radiospectroscopy, Jagiellonian University,
Krakow, Malopolskie, Poland,
2
Pedagogical
University, Krakow, Malopolskie, Poland
The new results obtained by NMR relaxation method,
namely the time evolution of relaxation time in blood
serum, after initiation of oxidation process by addition
of H2O2 are presented. Hydrogen peroxide is one of the
strongest reactive oxygen species and when added to
aqueous solutions it causes changes of the water proton
relaxation times. Just after H2O2 addition to protein
solution samples the relaxation time starts to short and
after approximately 25 minutes stabilizes. In serum,
after reaching the minimum value T1 instead of
stabilization starts to regrow. It means that this
regrow might be a consequence of the action of
antioxidants which are known to be present in blood
serum. We hope NMR relaxation measurements may be useful
in diagnosis of some diseases, specially with free
radical background.
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