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Abstract #3267

Blood serum demonstrates antioxidative mechanism: a Magnetic Resonance Relaxation Studies

Lech Wiktor Skorski 1 , Dorota Wierzuchowska 2 , and Barbara Blicharska 1

1 Radiospectroscopy, Jagiellonian University, Krakow, Malopolskie, Poland, 2 Pedagogical University, Krakow, Malopolskie, Poland

The new results obtained by NMR relaxation method, namely the time evolution of relaxation time in blood serum, after initiation of oxidation process by addition of H2O2 are presented. Hydrogen peroxide is one of the strongest reactive oxygen species and when added to aqueous solutions it causes changes of the water proton relaxation times. Just after H2O2 addition to protein solution samples the relaxation time starts to short and after approximately 25 minutes stabilizes. In serum, after reaching the minimum value T1 instead of stabilization starts to regrow. It means that this regrow might be a consequence of the action of antioxidants which are known to be present in blood serum. We hope NMR relaxation measurements may be useful in diagnosis of some diseases, specially with free radical background.

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