Non-linear relationship between estimated liver iron concentration and R2*
Erik M. Akkerman 1 , Jurgen H. Runge 1 , Marian A. Troelstra 1 , Aart J. Nederveen 1 , and Jaap Stoker 1
Radiology, Academic Medical Centre,
Amsterdam, North Holland, Netherlands
From 01-2008 until 12-2013 we performed MR-measurements
of liver iron content (LIC) in 95 patients, using a
standardized protocol, including R2*-measurement, and
LIC-assessment following Gandon's method. To optimize
B0-homogeneity, we measured only three slices
simultaneously, with shimming performed on a manually
defined region, excluding arms and air. The same liver
ROIs were used to analyze both methods. The resulting
relation between R2* and estimated LIC showed a low
error variation and was significantly non-linear. It
could be well described by a quadratic function.
Previous publications only reported linear relations,
probably due to a higher accuracy in our measurements.
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