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Abstract #3268

Non-linear relationship between estimated liver iron concentration and R2*

Erik M. Akkerman 1 , Jurgen H. Runge 1 , Marian A. Troelstra 1 , Aart J. Nederveen 1 , and Jaap Stoker 1

1 Radiology, Academic Medical Centre, Amsterdam, North Holland, Netherlands

From 01-2008 until 12-2013 we performed MR-measurements of liver iron content (LIC) in 95 patients, using a standardized protocol, including R2*-measurement, and LIC-assessment following Gandon's method. To optimize B0-homogeneity, we measured only three slices simultaneously, with shimming performed on a manually defined region, excluding arms and air. The same liver ROIs were used to analyze both methods. The resulting relation between R2* and estimated LIC showed a low error variation and was significantly non-linear. It could be well described by a quadratic function. Previous publications only reported linear relations, probably due to a higher accuracy in our measurements.

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