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Abstract #3272

Correction for T1 effects on MRI estimation of muscle sodium levels

Ping Wang 1 , Isaac V Manzanera Esteve 1 , Charles Nockowski 2 , and John C Gore 1

1 Vanderbilt University Institute of Imaging Science, Nashville, TN, United States, 2 Philips Healthcare Technical Support at Vanderbilt, Nashville, TN, United States

The effects of T1 on estimates of sodium content in human muscle have been evaluated. Our data confirm that sodium levels estimated by comparing MRI signals to calibration phantoms are inaccurate unless the relaxation times of the tissue and phantom match, or unless longer TR values are used so that both tissue and phantom are fully relaxed. When simple solutions of sodium are used as references standards, if TR is greater than 130ms, the relative error in the reported tissue sodium content is reduced to < 5%.

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