Abstract #3273
Excretion rate and distribution volumes in common marmoset monkeys after slow and fast injection of Gadobutrol
Gunther Helms 1,2 , Christina Schlumbohm 3 , Enrique Garea-Rodriguez 4,5 , and Eberhard Fuchs 5
1
Medical Radiation Physics, Lund University,
Lund, Scania, Sweden,
2
Cognitive
Neurology, Gttingen University Medical Center,
Gttingen, Lower Saxony, Germany,
3
Encepharm
Inc., Gttingen, Lower Saxony, Germany,
4
Neuroanatomy,
Albert-Ludwigs-University Freiburg, Freiburg, Badenia,
Germany,
5
Clinical
Neurobiology Group, German Primate Center, Gttingen,
Lower Saxony, Germany
Common marmoset monkeys (Callithrix jacchus) are
increasingly used in models of neurodegenerative
diseases. Serial measurements of gadolinium excretion
were performed using the dual flip angle method to map
R1 on three animals in the wrist coil of a 3T whole-body
system. R1 values were analyzed in a ROI in the straight
sinus and fitted with a single compartment model. Slow
injection of 0.3 mmol Gadovist per kg bodyweight (2 min
duration) resulted in faster equilibration and
excretion, as well as smaller distribution volumes than
fast injection (15 sec). Slow injection and an
equilibration delay of 15 minutes are recommended.
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