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Abstract #3273

Excretion rate and distribution volumes in common marmoset monkeys after slow and fast injection of Gadobutrol

Gunther Helms 1,2 , Christina Schlumbohm 3 , Enrique Garea-Rodriguez 4,5 , and Eberhard Fuchs 5

1 Medical Radiation Physics, Lund University, Lund, Scania, Sweden, 2 Cognitive Neurology, Gttingen University Medical Center, Gttingen, Lower Saxony, Germany, 3 Encepharm Inc., Gttingen, Lower Saxony, Germany, 4 Neuroanatomy, Albert-Ludwigs-University Freiburg, Freiburg, Badenia, Germany, 5 Clinical Neurobiology Group, German Primate Center, Gttingen, Lower Saxony, Germany

Common marmoset monkeys (Callithrix jacchus) are increasingly used in models of neurodegenerative diseases. Serial measurements of gadolinium excretion were performed using the dual flip angle method to map R1 on three animals in the wrist coil of a 3T whole-body system. R1 values were analyzed in a ROI in the straight sinus and fitted with a single compartment model. Slow injection of 0.3 mmol Gadovist per kg bodyweight (2 min duration) resulted in faster equilibration and excretion, as well as smaller distribution volumes than fast injection (15 sec). Slow injection and an equilibration delay of 15 minutes are recommended.

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