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Abstract #3274

Riboflavin (vitamin B2) may be used as a potential chelate in Wilson disease: Magnetic resonance relaxation study

Lech Wiktor Skorski 1 and Barbara Blicharska 2

1 Radiospectroscopy, Jagiellonian University, Krakow, Malopolskie, Poland, 2 Radiospectroscopy, Jagiellonian University, Malopolskie, Poland

It is well known that the presence of free paramagnetic ions shortens the NMR relaxation times of blood serum. Addition of the selective chelating agent (i.e.: D-penicillamine (D-pen) to serum causes the formation of stable and water soluble complexes of free ions and this nulls the effect of shortening of relaxation times of solution. After chelation one can easily measure the prolongation of relaxation times and this fact can be used as evidence of presence of free ions in blood serum. Obtained results confirm that the chelate action of Riboflavin (Vit.B2) is very similar to action of D-pen, but riboflavin as a natural product, have much smaller side effects and will be better tolerably for patients as D-pen.

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