Abstract #3277
Myelin and More: mcDESPOT Applied to Post Mortem Multiple Sclerosis Spinal Cord
Amy R. McDowell 1 , Tobias C. Wood 2 , Natalia Petrova 1 , Daniele Carassiti 1 , Marc Miquel 3 , David Thomas 4 , Gareth J. Barker 2 , and Klaus Schmierer 5,6
1
Blizard Institute, Queen Marys University of
London, London, United Kingdom,
2
Neuroimaging,
King's College London, London, United Kingdom,
3
Clinical
Physics, Barts Health NHS Trust, London, United Kingdom,
4
UCL
Institute of Neurology, London, United Kingdom,
5
Barts
and The London School of Medicine & Dentistry, Blizard
Institute, London, Greater London, United Kingdom,
6
Neurology,
Barts Health NHS Trust, London, Greater London, United
Kingdom
Steady-state methods allow time-efficient quantification
of relaxation time constants T1 and T2 via the Variable
Flip Angle or DESPOT1/2 method. By combining T1 and T2
information, separate water compartments are identified
with short, medium and long T2 values, corresponding to
myelin water, intra/extra-cellular water, and free
water. To validate quantitative MR compartment maps
derived from mcDESPOT we applied this technique to post
mortem MS spinal cord samples subsequently processed for
histology to explore myelin distribution and
cellularity. Good correspondence was detected between
MWF and myelination, and FWF and cellularity.
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