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Abstract #3277

Myelin and More: mcDESPOT Applied to Post Mortem Multiple Sclerosis Spinal Cord

Amy R. McDowell 1 , Tobias C. Wood 2 , Natalia Petrova 1 , Daniele Carassiti 1 , Marc Miquel 3 , David Thomas 4 , Gareth J. Barker 2 , and Klaus Schmierer 5,6

1 Blizard Institute, Queen Marys University of London, London, United Kingdom, 2 Neuroimaging, King's College London, London, United Kingdom, 3 Clinical Physics, Barts Health NHS Trust, London, United Kingdom, 4 UCL Institute of Neurology, London, United Kingdom, 5 Barts and The London School of Medicine & Dentistry, Blizard Institute, London, Greater London, United Kingdom, 6 Neurology, Barts Health NHS Trust, London, Greater London, United Kingdom

Steady-state methods allow time-efficient quantification of relaxation time constants T1 and T2 via the Variable Flip Angle or DESPOT1/2 method. By combining T1 and T2 information, separate water compartments are identified with short, medium and long T2 values, corresponding to myelin water, intra/extra-cellular water, and free water. To validate quantitative MR compartment maps derived from mcDESPOT we applied this technique to post mortem MS spinal cord samples subsequently processed for histology to explore myelin distribution and cellularity. Good correspondence was detected between MWF and myelination, and FWF and cellularity.

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