Abstract #3278
A fast method for T1 and T2 mapping of cerebrospinal fluid at 7T
Jolanda M Spijkerman 1 , Esben T Petersen 1,2 , Peter Luijten 1 , Jeroen Hendrikse 1 , and Jaco J Zwanenburg 1
1
Radiology, University Medical Center
Utrecht, Utrecht, Utrecht, Netherlands,
2
Radiotherapy,
University Medical Center Utrecht, Utrecht, Utrecht,
Netherlands
The oxygen sensitivity of T1/T2 of cerebrospinal fluid
(CSF) may allow non-invasive assessment of oxygen
content in ageing and disease. An MLEV pulse sequence
was developed for T1/T2 mapping of CSF at high field
strength (7 Tesla). A water phantom was used for
characterizing B0 and B1 dependency, and reference T1
and T2 maps were made. The T1/T2 were underestimated
with the MLEV sequence, but relatively insensitive to
B0/B1 variations for B0 offsets < 50Hz and B1 between
80-110%. In vivo results (n=4) were comparable to
literature, and showed lower T1/T2 in the peripheral
subarachnoid spaces compared to the ventricles.
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