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Abstract #3280

Quantification of Myelin Degeneration in Multiple Sclerosis within Clinical Scan Times.

L. Soustelle 1,2 , O. Commowick 1 , E. Bannier 1,3 , and C. Barillot 1

1 Unit VISAGES U746 INSERM-INRIA, IRISA UMR CNRS 6074, University of Rennes, Rennes, France, 2 Universit de Strasbourg, CNRS, ICube, FMTS, Strasbourg, France, 3 Radiology Dept., University Hospital of Rennes, F-35043 Rennes, France

Myelin Water Fraction is a validated measure of myelin density. The proposed approach makes use of recent spatial regularization methods for MWF estimation from clinically compatible acquisitions (typically 11 echoes acquired within 6 minutes). The algorithms were evaluated on both synthetic and clinical data for cross-validation strategy.

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