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Abstract #3282

Reproducibility and Sensitivity of T 2 * Measured in Patients with Squamous Cell Carcinoma of the Head and Neck at 3T

Rafal Panek 1 , Liam Welsh 1 , Maria A. Schmidt 1 , Alex Dunlop 1 , Kate L. Newbold 1 , Kee Wong 1 , Angela M. Riddell 1 , Dow-Mu Koh 1 , Dualta Mcquaid 1 , Shreerang A. Bhide 1 , Kevin J. Harrington 2 , Christopher M. Nutting 2 , Georgina Hopkinson 3 , Cheryl Richardson 3 , Simon P. Robinson 4 , and Martin O. Leach 1

1 Royal Marsden NHS FT and Institute of Cancer Research, Sutton, Surrey, United Kingdom, 2 Royal Marsden NHS FT and Institute of Cancer Research, London, United Kingdom, 3 Royal Marsden NHS FT, London, United Kingdom, 4 Institute of Cancer Research, Sutton, Surrey, United Kingdom

In this study, the reproducibility of T2* was calculated, and blood oxygen saturation dependence of tissue relaxation times simulated, for patients with squamous cell carcinoma of the head and neck at 3T. The simulation of tissue T2* shows that the sensitivity of the method increases as a function of blood oxygenation, and is sufficient for the majority of SCCHN oxygen tensions, with the exception of anoxic and severely hypoxic tumour regions where sensitivity is lower than reproducibility coefficient (11%). Both baseline T2* values and blood volumes should be taken into account when employing changes in T2* for assessing tissue oxygenation.

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