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Abstract #3330

Improved Accuracy in Susceptibility-based OEF Measurements by Mitigation of Partial-Volume Effects via Combined Magnitude and Phase Reconstruction

Patrick McDaniel 1 , Audrey Fan 2 , Berkin Bilgic 3 , Jeffrey N. Stout 4 , and Elfar Adalsteinsson 1,4

1 Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States, 2 Radiology, Richard M. Lucas Center for Imaging, Stanford University, Stanford, CA, United States, 3 A. A. Martinos Center for Imaging, Department of Radiology, Massachusetts General Hopsital, Charlestown, MA, United States, 4 Health Sciences and Technology, Harvard-MIT, Cambridge, MA, United States

Regional quantitative Oxygen Extraction Fraction (OEF) values measured using MRI phase data are clinically valuable, but can only be reliably obtained from blood vessels larger than the acquisition voxel size. Blood vessels beyond this limit produce unreliable measurements because of partial-volume effects. We demonstrate a method for obtaining more reliable OEF measurements beyond this limit by amending the conventional phase-based reconstruction with additional information contained in the magnitude of the complex-valued MR signal. The method is validated on numerical and in vivo data over a range of voxel sizes from to 3 times the vessel diameter.

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