Abstract #3330
Improved Accuracy in Susceptibility-based OEF Measurements by Mitigation of Partial-Volume Effects via Combined Magnitude and Phase Reconstruction
Patrick McDaniel 1 , Audrey Fan 2 , Berkin Bilgic 3 , Jeffrey N. Stout 4 , and Elfar Adalsteinsson 1,4
1
Electrical Engineering and Computer Science,
Massachusetts Institute of Technology, Cambridge, MA,
United States,
2
Radiology,
Richard M. Lucas Center for Imaging, Stanford
University, Stanford, CA, United States,
3
A.
A. Martinos Center for Imaging, Department of Radiology,
Massachusetts General Hopsital, Charlestown, MA, United
States,
4
Health
Sciences and Technology, Harvard-MIT, Cambridge, MA,
United States
Regional quantitative Oxygen Extraction Fraction (OEF)
values measured using MRI phase data are clinically
valuable, but can only be reliably obtained from blood
vessels larger than the acquisition voxel size. Blood
vessels beyond this limit produce unreliable
measurements because of partial-volume effects. We
demonstrate a method for obtaining more reliable OEF
measurements beyond this limit by amending the
conventional phase-based reconstruction with additional
information contained in the magnitude of the
complex-valued MR signal. The method is validated on
numerical and in vivo data over a range of voxel sizes
from to 3 times the vessel diameter.
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