Abstract #3331
On the limitations of brain lesion characterization by direct assessment of MRI phase
Paul Polak 1 , Robert Zivadinov 1,2 , and Ferdinand Schweser 1,2
1
Department of Neurology, Buffalo
Neuroimaging Analysis Center, State University of New
York at Buffalo, Buffalo, NY, United States,
2
Molecular
and Translational Imaging Center, MRI Center, Clincal
and Translational Research Center, Buffalo, NY, United
States
Differentiation of hemorrhagic and calcified brain
lesions is an important clinical neuroimaging task. The
gold-standard technique uses computed tomography,
although the use of susceptibility weighted phase images
has been the subject of intense research. On the basis
that hemorrhages are paramagnetic, and calcifications
diamagnetic, the phase of the lesion can be used as the
criterion for differentiation. In numerical simulations
of an elliptical lesion we demonstrated that the
internal phase also depends on the lesions orientation
in the magnetic field, and thus phase is an unreliable
standard for lesion discrimination. Quantitative
susceptibility maps derived from the phase images
correctly recovered the underlying susceptibility
regardless of positioning, and thus are a better
differentiator of lesion subtypes.
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