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Abstract #3334

R 1 Correction for Quantitative Amide Proton Transfer Imaging

Hua Li 1 , Ke Li 1 , Xiao-Yong Zhang 1 , Zhongliang Zu 1 , Moritz Zaiss 2 , Daniel F. Gochberg 1 , John C. Gore 1 , and Junzhong Xu 1

1 Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, 2 Department of Medical Physics in Radiology, DKFZ, Heidelberg, BW, Germany

Amide proton transfer (APT) imaging has been suggested as a surrogate biomarker of endogenous mobile proteins and peptides. However, conventional APT analyses using magnetization transfer asymmetry, may be significantly influenced by various confounding effects, such as MT, R1, and direct saturation. Previously reported R1 correction approaches are based on a simplified two-pool (water and amide protons) model. However, in biological tissues, water exists in multiple compartments. In this study, Gd-DTPA was introduced into tissue in order to selectively alter extracellular relaxation in tumors. By such a means, the accuracy of R1 corrections for APT imaging was evaluated in vivo.

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