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Abstract #3336

Applying variable RF-power CEST (vCEST) to detect exchangeable hydroxyl protons in the presence of MT at 3 Tesla

Daniel James Clark 1,2 , Alex K Smith 3,4 , Michael V Knopp 1 , and Seth A Smith 3,4

1 Wright Center of Innovation, Department of Radiology, The Ohio State University, Columbus, OH, United States, 2 Department of Biomedical Engineering, The Ohio State University, Columbus, OH, United States, 3 VUIIS, Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, 4 Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States

In this study we show that a variable RF pre-saturation power CEST scheme (vCEST) is feasible in vivo. Agar gel phantoms with glucose are used to show vCEST is sensitive to hydroxyl moieties in the presence of MT. Additionally, two subjects with prior ACL injuries are imaged at 3T and vCEST is used to observe detailed features of cartilage that are not present with conventional CEST.

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