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Abstract #3337

Improving sensitivity to hydroxyl protons and simultaneous measurement of amide and NOE signals at 3T using variable pre-saturation power CEST (vCEST)

Daniel James Clark 1,2 , Alex K Smith 3,4 , Michael V Knopp 1 , and Seth A Smith 3,4

1 Wright Center of Innovation, Department of Radiology, The Ohio State University, Columbus, OH, United States, 2 Department of Biomedical Engineering, The Ohio State University, Columbus, OH, United States, 3 VUIIS, Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, 4 Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States

This study presents theory, simulation, and phantom data for a variable RF pre-saturation power CEST sequence (vCEST) that is promising for hydroxyl detection and simultaneous measurements of amine and NOE signals at 3T. Glycogen and glucose phantoms of varying concentrations were used to show the increased sensitivity to hydroxyl protons. Glycogen and BSA phantoms were used to show that hydroxyl, amide, and NOE signals can be measured simultaneously in a single z-spectrum.

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