Abstract #3338
Saturation parameters influence on SAFARI performance
Shu Zhang 1 , Jochen Keupp 2 , Zheng Liu 3 , Robert E. Lenkinski 1,4 , and Elena Vinogradov 1,4
1
Radiology, UT Southwestern Medical Center,
Dallas, TX, United States,
2
Philips
Research, Hamburg, Germany,
3
Advanced
Imaging Research Center, Oregon Health & Science
University, Portland, OR, United States,
4
Advanced
Imaging Research Center, UT Southwestern Medical Center,
Dallas, TX, United States
This abstract studied the dependence of saturation with
frequency alternating RF irradiation (SAFARI) on pulsed
RF saturation parameters via simulation and phantom
experiments. Overall, both APT and SAFARI effects show
oscillations and decrease with increasing interpulse
delay. The amount of decrease is dependent on RF
parameters and the exchange rate. SAFARI is more
sensitive to the individual pulse length. Inversion
pulses lead to the most efficient saturation. Therefore,
efficient saturation can be achieved with increased
interpulse delay, thus lowering SAR without compromising
CEST effect. The study provides insights for further
sequence optimization to be used in various
applications.
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