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Abstract #3338

Saturation parameters influence on SAFARI performance

Shu Zhang 1 , Jochen Keupp 2 , Zheng Liu 3 , Robert E. Lenkinski 1,4 , and Elena Vinogradov 1,4

1 Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 2 Philips Research, Hamburg, Germany, 3 Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, 4 Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States

This abstract studied the dependence of saturation with frequency alternating RF irradiation (SAFARI) on pulsed RF saturation parameters via simulation and phantom experiments. Overall, both APT and SAFARI effects show oscillations and decrease with increasing interpulse delay. The amount of decrease is dependent on RF parameters and the exchange rate. SAFARI is more sensitive to the individual pulse length. Inversion pulses lead to the most efficient saturation. Therefore, efficient saturation can be achieved with increased interpulse delay, thus lowering SAR without compromising CEST effect. The study provides insights for further sequence optimization to be used in various applications.

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