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Abstract #3342

On the selection of reference images used for registration in CEST imaging

Yi Zhang 1 , Hye-Young Heo 1 , Dong-Hoon Lee 1 , and Jinyuan Zhou 1,2

1 Division of MR Research, Department of Radiolgoy, Johns Hopkins University, Baltimore, Maryland, United States, 2 F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, United States

Image registration has been widely used as a preprocessing step for ensuring high-quality CEST images, especially for in vivo human applications. The reference image indispensable for registration has been mostly chosen as the unsaturated image in literature. However, there is no report on whether the unsaturated image is the proper choice for the reference image. Here, its shown that referencing to the unsaturated image actually degrades the quality of CEST images, and the 3.5 ppm dynamic is the best reference for amide proton transfer imaging.

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