On the selection of reference images used for registration in CEST imaging
Yi Zhang 1 , Hye-Young Heo 1 , Dong-Hoon Lee 1 , and Jinyuan Zhou 1,2
Division of MR Research, Department of
Radiolgoy, Johns Hopkins University, Baltimore,
Maryland, United States,
M. Kirby Research Center for Functional Brain Imaging,
Kennedy Krieger Institute, Baltimore, Maryland, United
Image registration has been widely used as a
preprocessing step for ensuring high-quality CEST
images, especially for in vivo human applications. The
reference image indispensable for registration has been
mostly chosen as the unsaturated image in literature.
However, there is no report on whether the unsaturated
image is the proper choice for the reference image.
Here, its shown that referencing to the unsaturated
image actually degrades the quality of CEST images, and
the 3.5 ppm dynamic is the best reference for amide
proton transfer imaging.
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