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Abstract #3356

Whole Brain inhomogeneous MT using an ihMT prepared 3D GRE sequence at 1.5T

Olivier M. Girard 1 , Arnaud Le Troter 1 , Gopal Varma 2 , Valentin H. Prevost 1 , Maxime Guye 1,3 , Jean-Philippe Ranjeva 1,3 , David C. Alsop 2 , and Guillaume Duhamel 1

1 CRMBM UMR 7339, CNRS and Aix-Marseille University, Marseille, France, 2 Radiology Department, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States, 3 Ple d'Imagerie Mdicale, CEMEREM, APHM, Marseille, France

Inhomogeneous Magnetization Transfer (ihMT) has been proposed as a new technique that provides specific signal from myelinated tissues. 3D ihMT has been previously demonstrated at 3T and highlighted challenges, such as power limitation and non-uniformity of the resulting contrast. This work presents a 3D ihMT prepared GRE sequence implemented at 1.5T, allowing for stronger B 1 and better RF uniformity. Distributions of ihMTR and MTR across the whole brain demonstrated notable differences, and provided great insight for WM characterization. This opens new horizons for future work on WM microstructure and to study diffuse WM pathology such as MS.

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