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Abstract #3357

Extracting a robust inhomogeneous magnetization transfer (ihMT) rate parameter, ihMT- R ex

Gopal Varma 1 , Olivier M Girard 2 , Valentin Prvost 2 , Guillaume Duhamel 2 , and David C Alsop 1

1 Radiology, Division of MR Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States, 2 CRMBM UMR 7339, CNRS and Aix-Marseille Universit, Marseille, France

Inhomogeneous magnetization transfer (ihMT) shows promise for myelin selective imaging. As with other saturation based techniques, use of the ihMT ratio for quantification is complicated by other contributions, such as T 1 and B 1 inhomogeneity. Examination of the steady-state signal equation with saturation suggests use of the inverse signal and normalization with a high flip-angle (unsaturated) reference can help eliminate these dependencies. Application to ihMT data showed the resultant ihMT- R ex parameter to be B 1 independent for ihMT saturations of B 1,RMS ≥ 50mG. Maps of ihMT- R ex provided sharper and more uniform contrast within white matter.

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