Abstract #3359
Optimisation of Magnetisation Transfer Ratio sequence acquisition parameters: application to the spinal cord
Marco Battiston 1 , James E M Fairney 2,3 , Marios C Yiannakas 1 , Claudia A M Wheeler-Kingshott 1 , and Rebecca S Samson 1
1
NMR Research Unit, Department of
Neuroinflammation, Queen Square MS Centre, UCL Institute
of Neurology, London, England, United Kingdom,
2
Department
of Medical Physics and Biomedical Engineering, UCL,
London, England, United Kingdom,
3
Department
of Brain Repair and Rehabilitation, UCL Institute of
Neurology, London, England, United Kingdom
Magnetisation Transfer Ratio (MTR) has previously been
measured to detect abnormalities in brain and spinal
cord (SC) in a range of pathologies. However, the MTR is
influenced by several confounding factors that can
reduce its sensitivity to the underlying MT effect and
compromise its ability to differentiate tissue types and
pathological changes especially in the SC where
quantitative measurements are hampered by several
technical challenges. Here, we show how MTR sequence
parameters can be optimised to improve its sensitivity
to macromolecular content of the tissue, providing
enhanced contrast between different tissue types. An
application in the SC is presented.
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