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Abstract #3359

Optimisation of Magnetisation Transfer Ratio sequence acquisition parameters: application to the spinal cord

Marco Battiston 1 , James E M Fairney 2,3 , Marios C Yiannakas 1 , Claudia A M Wheeler-Kingshott 1 , and Rebecca S Samson 1

1 NMR Research Unit, Department of Neuroinflammation, Queen Square MS Centre, UCL Institute of Neurology, London, England, United Kingdom, 2 Department of Medical Physics and Biomedical Engineering, UCL, London, England, United Kingdom, 3 Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, England, United Kingdom

Magnetisation Transfer Ratio (MTR) has previously been measured to detect abnormalities in brain and spinal cord (SC) in a range of pathologies. However, the MTR is influenced by several confounding factors that can reduce its sensitivity to the underlying MT effect and compromise its ability to differentiate tissue types and pathological changes especially in the SC where quantitative measurements are hampered by several technical challenges. Here, we show how MTR sequence parameters can be optimised to improve its sensitivity to macromolecular content of the tissue, providing enhanced contrast between different tissue types. An application in the SC is presented.

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