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Abstract #3360

Correction for residual effects of B1+ inhomogeniety on MT saturation in FLASH-based multi-parameter mapping of the brain

Gunther Helms 1,2

1 Medical Radiation Physics, Lund University, Lund, Scania, Sweden, 2 Cognitive Neurology, Gttingen University Medical Center, Gttingen, Lower Saxony, Germany

Maps of the MT-saturation as derived in FLASH-based multi-parameter mapping (MPM) are largely corrected for effects of flip angle inhomogeneity. Here, we present a heuristic model for residual effects of B1+ that is rooted in the dynamics of macromolecule saturation. Model parameters were validated for brain tissues by variation of the MT-pulse flip angle in an established MPM protocol. White and gray matter exhibited similar values. A post-hoc correction by an independent B1+ map yielded more symmetric MT maps and reduced variation across white matter.

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